Sprim Publications

SPRIM is an integrated, global health innovation centered firm, with practice areas that include: Strategy & Innovation (SI), Regulatory and Scientific Affairs (RSA), Research and Clinical Services (RCS), Health Marketing and Communication (HMC). More at www.sprim.com Research & Clinical Services is the Contract Research Organization (CRO) arm of SPRIM Our CRO portfolio focuses on Fast Moving Consumer Health with a global experience on Nutrition, Personal Care, Cosmetics and Late Stage Pharma.


Homozygous mutation in MFSD2A, encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination

Springer Nature, July 2018

Tamar Harel & Debra Q. Y. Quek & Bernice H. Wong & Amaury Cazenave-Gassiot & Markus R. Wenk & Hao Fan & Itai Berger & Dorit Shmueli & Avraham Shaag & David L. Silver & Orly Elpeleg & Shimon Edvardson

PubMed DOI 10.1007/s10048-018-0556-6


A Deep Learning Method to Automatically Identify Reports of Scientifically Rigorous Clinical Research from the Biomedical Literature: Comparative Analytic Study

Journal of Medical Internet Research, June 2018

Guilherme Del Fiol , MD, PhD; Matthew Michelson , PhD; Alfonso Iorio , MD, PhD; Chris Cotoi , BEng, EMBA; R Brian Haynes, MD, PhD

PubMed DOI 10.2196/10281


Prevalence of general obesity and abdominal obesity in the Spanish adult population (Aged 25-64 Years) 2014-2015 : The ENPE Study

Revista Española de Cardiología 2016

Javier Aranceta-Bartrina, Carmen Pe´rez-Rodrigob, Goiuri Alberdi-Arestib,Natalia Ramos-Carrerafy Sonia La´zaro-Masedof

PubMed 27133458 DOI 10.1016/j.rec.2016.02.009


Comparison of 16 blood and/or elastometric fibrosis tests in 5 causes of chronic liver diseases: too much? Towards a simplification

Abstract, 2015

Jerome Boursier, Alexandra Ducancelle, Vincent Leroy, Julien Vergniol, Nathalie Sturm, Brigitte Le Bail, Jean- Pierre H. Zarski, Victor de Ledinghen

PubMed DOI


Inactivating mutations in MFSD2A, required for omega-3 fatty acid transport in brain, cause a lethal microcephaly syndrome

Nature Genetics, 2015

Alicia Guemez-Gamboa, Long N Nguyen, Hongbo Yang, Maha S Zaki, Majdi Kara, Tawfeg Ben-Omran, Naiara Akizu, Rasim Ozgur Rosti, Basak Rosti, Eric Scott, Jana Schroth, Brett Copeland, Keith K Vaux, Amaury Cazenave-Gassiot, Debra Q Y Quek, Bernice H Wong, Bryan C Tan, Markus R Wenk, Murat Gunel, Stacey Gabriel, Neil C Chi, David L Silver & Joseph G Gleeson

PubMed 26005868 DOI 10.1038/ng.3311


A partially inactivating mutation in the sodium-dependent lysophosphatidylcholine transporter MFSD2A causes a non-lethal microcephaly syndrome

Nature Genetics, 2015

Vafa Alakbarzade1, Abdul Hameed, Debra Q Y Quek, Barry A Chioza, Emma L Baple, Amaury Cazenave-Gassiot, Long N Nguyen, Markus R Wenk, Arshia Q Ahmad, Ajith Sreekantan-Nair, Michael N Weedon, Phil Rich, Michael A Patton, Thomas T Warner, David L Silver & Andrew H Crosby

PubMed 26005865 DOI 10.1038/ng.3313


Comparative 10-Years Prognosis of Fibrotest (FT) and Liver Stiffness Measurement (LSM) by Transient Elastog-raphy (TE, Fibroscan) in 9364 Chronic Liver Diseases (CLD) Patients (Pts)

Abstract, 2015

Mona Munteanu, Yen Ngo, Hugo Perazzo, Pascal Lebray, Helmi Mkada, Olivier Deckmyn, Denis Monneret, Françoise Imbert-Bismut, Dominique Bonnefont-Rousselot, Vincent Thi-bault, Vlad Ratziu, Chantal Housset, Thierry Poynard

PubMed DOI


Modelling epidermis homoeostasis and psoriasis pathogenesis

Journal of the Royal Society, Interface, 2015

Hong Zhang , Wenhong Hou , Laurence Henrot , Sylvianne Schnebert , Marc Dumas , Catherine Heusèle , Jin Yang

PubMed 25566881 DOI 10.1098/rsif.2014.1071


Liver Fibrosis Epidemiology Revisited Using Software Combined Biomarker: Proof of Concept Using 1,081,658 Centralised Fibrotest (FT) Prescriptions

Poster, 2015

Thierry Poynard on behalf of FibroFRANCE, Olivier Deckmyn, Joe Sebastian , Mona Munteanu, Yen Ngo, Fabienne Drane, Janet Quee, Jean Marie Castille

PubMed DOI


Prognostic value of liver fibrosis and steatosis biomarkers in type-2 diabetes and dyslipidaemia

Alimentary Pharmacology and Therapeutics, 2014

H. Perazzo, M. Munteanu, Y. Ngo, P. Lebray, N. Seurat, F. Rutka, M. Couteau, S. Jacqueminet P. Giral, D. Monneret, F. Imbert-Bismut, V. Ratziu, A. Hartemann-Huertier, C. Housset, T. Poynard & for the FLIP Consortium

PubMed 25186086 DOI 10.1111/apt.12946


Effect of maltitol or xylitol sugar-free chewing gums on plaque parameters related to dental caries development

European Journal of Paediatric Dentistry, Dec 2013

Thabuis C, Cheng CY, Wang X, Pochat M, Han A, Miller L, Wils D, Guerin-Deremaux L

PubMed 24313583 DOI


Insulin resistance and adipose derived hormones in young men with untreated obstructive sleep apnea

Sleep and Breathing, March 2013

Hargens TA, Guill SG, Kaleth AS, Nickols-Richardson SM, Miller LE, Zedalis D, Gregg JM, Gwazdauskas F, Herbert WG

PubMed 22528956 DOI 10.1007/s11325-012-0708-0


Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children

Cochrane Library, 2013

Hong Zhang , Wenhong Hou , Laurence Henrot , Sylvianne Schnebert , Marc Dumas , Catherine Heusèle , Jin Yang

PubMed 23728658 DOI 10.1002/14651858.CD006095.pub3.


Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice — an evidence-based international guide

Alimentary Pharmacology & Therapeutics, 2013

Hungin AP, Mulligan C, Pot B, Whorwell P, Agréus L, Fracasso P, Lionis C, Mendive J, Philippart de Foy JM, Rubin G, Winchester C, de Wit N; European Society for Primary Care Gastroenterology.

PubMed 23981066 DOI 10.1111/apt.12460


History of frequent gum chewing is associated with higher unstimulated salivary flow rate and lower caries severity in healthy Chinese adults

Caries Research, 2012

Wang XP, Zhong B, Chen ZK, Stewart ME, Zhang C, Zhang K, Ni J, Dodds MW, Hanley AB, Miller LE

PubMed 22813956 DOI 10.1159/000339660


Evaluation of nutritional quality of Nutralys® pea protein

Journal of Nutraceuticals, Functional Foods and Healthy Ingredients, 2012

Yang H, Guérin-Deremaux L, Zhou L, Fratus A, Wils D, Zhang C, Zhang K, Miller LE

PubMed DOI


Nutritional modulation of age-related macular degeneration

Molecular Aspects of Medicine, 2012

Karen A, Weikel, Chiu CJ, Taylor A.

PubMed 22503690 DOI 10.1016/j.mam.2012.03.005.


Anti-inflammatory effects of Lacto-Wolfberry in a mouse model of experimental colitis

World Journal of Gastroenterology, 2012

Philippe D, Brahmbhatt V, Foata F, Saudan Y, Serrant P, Blum S, Benyacoub J, Vidal K.

PubMed 23082051 DOI 10.3748/wjg.v18.i38.5351


Goji berry effects on macular characteristics and plasma antioxidant levels

Optometry & Vision Science, 2011

Bucheli P, Vidal K, Shen L, Gu Z, Zhang C, Miller LE, Wang J

PubMed 21169874 DOI 10.1097/OPX.0b013e318205a18f


Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults

Scandinavian Journal of Gastroenterology, 2011

Waller PA, Gopal PK, Leyer GJ, Ouwehand AC, Reifer C, Stewart ME, Miller LE

PubMed PMC3171707 DOI 10.3109/00365521.2011.584895


Effects of Nutriose® dietary fiber supplementation on body weight, body composition, energy intake, and hunger in overweight men

International Journal of Food Sciences and Nutrition, 2011

Guerin-Deremaux L, Li S, Pochat M, Wils D, Mubasher M, Reifer C, Miller LE

PubMed 21591985 DOI 10.3109/02688697.2011.641613


Evaluation of bovine-derived lacteal complex supplementation on gene expression in BALB/c mice

Nutrition and Dietary Supplements, 2011

Clerici M, Pauze E, Jong AD, Biasin M, Miller LE

PubMed DOI 10.2147/NDS.S23701


Vancomycin or Metronidazole for Treatment of Clostridium difficile Infection: Clinical and Economic Analyses [Internet]

Cadth Technology Report, 2011

Perras C, Tsakonas E, Ndegwa S, Conly J, Valiquette L, Farrah K.

PubMed 24354025 DOI


Safety of probiotics used to reduce risk and prevent or treat disease

Evidence Report/Technology Assessment, 2011

Hempel S, Newberry S, Ruelaz A, Wang Z, Miles JN, Suttorp MJ, Johnsen B, Shanman R, Slusser W, Fu N, Smith A, Roth B, Polak J, Motala A, Perry T, Shekelle PG

PubMed 21901706 DOI


Early evidence of increased risk for metabolic syndrome in young men with latent obstructive sleep apnea

Metabolic Syndrome and Related Disorders, 2010

Guill S, Hargens T, Nickols-Richardson S, Bassaganya-Riera J, Miller L, Zedalis D, Gregg J, Gwazdauskas F, Herbert W

PubMed 19943797 DOI 10.1089/met.2009.0041


New orchid extract based technology for skin whitening

Chinese Journal of Disease Control & Prevention, 2010

PubMed DOI


Map of Digestive Disorders & Diseases

World Gastroenterology Organisation, 2008

Dr. Guarner, Ms Lázaro, Ms Gascón, Ms Royo, Dr. Eximan, Dr. Herrero

PubMed DOI